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Here's what FDA approvals, ADA guidelines and recent trials actually say.

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While the overall frequency of liver enzyme elevations across the over 1,400 participant safety database of danuglipron is in-line with approved agents in the class, a single asymptomatic participant in one of the dose-optimization studies experienced potential drug-induced liver injury which resolved after discontinuation of danuglipron

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Patients have found compounded semaglutide to be a cheaper, accessible GLP-1, but health experts warn of risks tied to the non-FDA-approved drugs.