endometriosis and glp 1 The hidden impact of GLP‐1 receptor agonists on endometrial receptivity implantation - Sola‐Leyva - 2025 - Acta Obstetricia et Gynecologica Scandinavica Treating Endometriosis Inflammation with GLP-1s

They found that GLP-1 users had a 45% reduced risk of developing dementia compared to those who didnt take these medications

By enhancing insulin sensitivity, GLUT4-mediated glucose uptake, and AMPK activity, GLP-1RAs improve skeletal muscle energy metabolism and reduce lipid accumulation in skeletal muscle

BMJ 2022;376:e066084

I do think tolerability of these drugs is still an issue

Some research suggests adding semaglutide (the active ingredient in Wegovy) to metformin may help improve blood sugar control and lead to more weight loss than metformin alone

Two 16-week phase 1 trials, one in subjects with obesity and another with T2D, shows significant reductions in body weight and HbA1c, respectively (95)