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Description
GLP-1 biosimilars are follow-on biologic or peptide therapeutics developed to demonstrate high similarity to approved GLP-1 receptor agonist drugs
Target Engagement Retatrutide engages GLP 1R, GIPR, and GCGR through direct peptide receptor binding that mimics the interaction of endogenous incretin and glucagon peptides
Retatrutide showed superior reductions in albuminuria, glomerular hypertrophy, and renal fibrosis markers
A separate 2024 study of 290 adults with obesity given oral semaglutide for three months found that free T3 decreased, free T4 rose slightly, and TSH fell during treatment
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