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To investigate the possible mechanism of PanIN progression in humans, Gier et al

In a phase 2 study, amycretin showed a mean weight reduction of up to 24.3%, which is comparable to or even greater than the weight loss seen with tirzepatide and similar to the results for retatrutide

Thus, we feel this can only be explained through a change in energy expenditure, and, since skeletal muscle is the primary target of GDF8, we hypothesize the change in energy expenditure is coming from this compartment

Obesity 30 , 841857 (2022)

Subscribing to journals, attending conferences, and reviewing clinical guidelines will help integrate new evidence into practice responsibly

doi: 10.1038/s41467-020-18751-8
