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And it changes how success should be measured: not as "I lost the weight and stopped," but as "I am managing a chronic condition that requires ongoing treatment." How to think about GLP-1 therapy None of this means stopping is never appropriate

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This, paired with the observation that GLP-1 can act as a neuroendocrine signalling peptide in the circulation tightly links central and peripheral GLP-1 signalling to the regulation of energy homeostasis and satiety

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