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The primary endpoint was to demonstrate non-inferiority (with a non-inferiority margin of 0.3%) of tirzepatide 10 mg or 15 mg, or both, compared to glargine in terms of the change in HbA1c from baseline to 52 weeks

The pressing question remains: how transformative will the introduction of these new weight loss drugs be across the broader healthcare landscape

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In fact, when appetite drops, nutrition often needs more attention, not less

A 2025 meta-analysis has also reported a similar trend after analyzing clinical trials and observational studies: tirzepatide produced about 4% greater weight loss than semaglutide [8]