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History of suicidal thinking Non-medullary thyroid cancer A family history of multiple endocrine neoplasia type 2 Because GLP-1s target the root causes of weight gain, many patients experience sustained weight loss after stopping the medication

Questions about dosing, side effects, or lifestyle adjustments can be answered day or night

Which days involve the most social eating

Clinical implication: clinicians should treat vaginal symptoms in patients taking semaglutide as real and addressable , but approach causality cautiously: prioritise common diagnoses (genitourinary syndrome of menopause, infections, dermatologic vulvar disease, STIs, irritant/contact dermatitis, pelvic floor disorders), identify important confounders (notably SGLT2 inhibitors, antibiotics, hormonal therapies), manage symptoms and underlying conditions, and report suspected adverse reactions when there is a reasonable temporal relationship and alternative causes are less likely

Constipation and diarrhea both appear in patient reports, sometimes alternating in the same patient across different weeks

The STEP trials (Semaglutide Treatment Effect in People with obesity) demonstrated 1022% body weight reduction over 68 weeks in adults with obesity, with sustained benefits during maintenance phases