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Beyond glucose control, GLP-1 RAs have gained prominence for their CV benefits, especially in individuals with established CVD

GLP-1R activation inhibits NF-kB through a series of complicated actions inside the cell, but ultimately for our purposes this leads to the downregulation of multiple inflammatory cytokines, including but not limited to Tumor Necrosis Factor Alpha, (TNF-a) Interleukin 6 and 1-beta (IL6 and IL-1b) and multiple others

This information is intended to support understanding, not replace personalised medical advice

Treatment response : As per NICE guidance, assess response after 6 months and continue only if adequate benefit is demonstrated (HbA1c reduction of at least 11 mmol/mol [1%] and/or 3% weight loss from initial body weight)

Patients can also explore options like copay cards and patient assistance programs to make the treatment more affordable

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