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Increased GIP signaling induces adipose inflammation via a HIF-1-dependent pathway and impairs insulin sensitivity in mice

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Metabolic changes induced by prednisolone further complicate weight management

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Nat Commun (2015) 6:7715.10.1038/ncomms8715 172 DuferMHorthKWagnerRSchittenhelmBProwaldSWagnerTFet alBile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and K(ATP) channel inhibition

It does not have FDA approval and should only be used under the supervision of a licensed healthcare provider