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New England Journal of Medicine 2021

While this can be beneficial for individuals with insulin resistance or type 2 diabetes, combining them without proper medical supervision could potentially lead to an excessive reduction in blood sugar, known as hypoglycemia

WCDD301 lowered plasma glucagon levels but did not alter glucagon-stimulated glucose output from primary mouse hepatocytes (Figure 6G), nor did it affect euglycemia in nondiabetic NOD mice (Supplemental Figure 6B)
