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During weight loss, the body naturally breaks down muscle tissue for energy if hormone levels are insufficient

Molecular Mechanism: The GLP-1R Signaling Pathway The expression of GLP-1R in the brain is not limited to neurons in specific brain regions including the frontal cortex, hypothalamus, thalamus, hippocampus, cerebellum, and substantia nigra but also includes microglial cells involved in neuroinflammation