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Compared with nonusers, adults taking GLP-1s had a: 17 percent lower risk of venous thromboembolism, or blood clots in the veins 31 percent lower risk of pulmonary embolism, a potentially life-threatening clot that travels to the lungs 21 percent lower risk of going to the emergency department 44 percent lower risk of all-cause mortality (death from any cause) Researchers also observed lower stroke rates among GLP-1 users, although this difference didnt reach statistical significance

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These findings highlight the potential clinical importance of achieving and maintaining weight loss after GLP-1-based treatment initiation. Meeting: European Congress on Obesity 2026 (ECO2026) Never miss a breakthrough: Join the SciTechDaily newsletter

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Patients with contraindications to GLP-1 agonists may explore older weight-loss medications like phentermine or orlistat, or consider non-pharmacologic approaches like intensive lifestyle modification and bariatric surgery consultation

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Potential Health Risks Pancreatitis Both medications have been associated with an increased risk of pancreatitis

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This review also highlights the existing queries and evidence gaps in DPP-4 inhibitor research

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Waterman and D

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