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Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes

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Secondary endpoints include change in neural response to visual food cues and to sweet-tasting substances as assessed by functional MRI, change in body weight, change in fat mass and change in eating behaviour and food intake

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Given the heterogeneity of the included evidencespanning case reports, pharmacovigilance analyses, and observational cohortsthis review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis