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The interaction between the upper gastrointestinal tract and the endocrine system is important in the regulation of metabolism and of weight (Figure1)

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### Competing Interest Statement ASK, AMM, MCG, JMD, CB, CL, SWB, DJL, PML, DRD, JMC, JPF, YL, ARS, DAT, DWP, SH, RBR, MSL, and DAG are employees and stockholders of Pfizer Inc

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