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This is supported by a study showing that re-introduction of GLP-1Rs into the POMC neurons of GLP-1R knockout mice did not reinstate weight loss in lean animals, but partially restored weight loss (~50%) in obese animals (196)
J Med Chem (2000) 43:16649
The standard minimum is 0.8 g/kg of body weight (about 0.36 g/lb) for an average sedentary adult
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Individuals with higher levels of insulin resistance may benefit more from VLEKT due to reduced insulin demand [133]
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