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For a full breakdown of what to anticipate by dose, see retatrutide side effects: what to expect

Weekly morning weigh-ins, taken on the same day at the same time before eating or drinking, provide more reliable trend data

Accelerated apparent aging: Paradoxically, users who lose large amounts of weight rapidly can look older immediately after the loss than they did before

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In brief, the SURPASS-2 trial randomly assigned individuals with type 2 diabetes in a 1:1:1:1 ratio, to receive tirzepatide at a dose of 5 mg, 10 mg or 15 mg or semaglutide at a dose of 1 mg