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The direct consequence of such a high dose is that the potency of the GLP-1 peptide component in the fusion had to be appropriately reduced to try minimising GLP-1-induced gastrointestinal side effects 18

The tendency to fluid retention is highly prevalent in diabetic kidney disease 34

Likewise, as patients progress and require triple therapy, these medication classes comprise options in combination with a variety of other antihyperglycemic medication classes

These symptoms may be more troublesome in older adults who suffer from fecal incontinence, and co-prescription of fat-soluble vitamins is needed to ensure adequate nutrition is maintained

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Exposing three human osteosarcoma cell lines expressing GIPRs (TE-85, MG-63, and Saos-2) to GIP resulted in the release of bone formation marker P1NP (Pacheco-Pantoja et al., 2011), in which the expression of Col-1 in Saos-2 cells increased (Mieczkowska et al., 2015)