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However, group differences appear to be small, and the efficacy of the muscarinic antagonists in the diabetic groups remained of clinical relevance
For example, an underdosed vial might leave you with no real benefits, while an overdosed one could increase the risk of side effects
It has been shown that pancreatic beta cells express the M3-muscarinic acetylcholine receptor

A recent US study showed that sulfonylureas and DPP-4i were the most common second antidiabetic add-on treatment (46 and 20%, respectively) [17]

This swelling can press on nerves, including the sciatic nerve, causing sharp or shooting pain down the back and legs (sciatica)

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