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Most recommendations are clear: Do not use the medication after the expiration date

Calcium- or iron-containing supplements: Many commercial weight loss products include added minerals

10.1016/j.molmet.2017.04.010 157

One study published in the New England Journal of Medicine found that patients using semaglutide for weight loss lost an average of 14.9% of their body weight over 68 weeks
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Side effects and tolerability Like other medications in the incretin class, retatrutide caused gastrointestinal side effects in some patients