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Weight loss continues but gradually decelerates as the body approaches a new equilibrium

Sequencing and Combination Use of SGLT2is and GLP-1 RAs There was agreement that sequential or upfront combination therapy with SGLT2is and GLP-1 RAs is appropriate for individuals with ongoing kidney progression, high cardiovascular risk or suboptimal metabolic control

It is to give it gentle, consistent support

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Science , 339(6119), 548554

Patients with previously uncontrolled type 2 diabetes often experience polyuria (excessive urination) due to glucose levels exceeding the renal threshold, causing glucose to spill into urine and draw water with it