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A phase 2 trial involving 338 adults with overweight status or obesity evaluated retatrutidea triple agonist for GLP-1, GIP, and glucagon receptorsfor weight loss over 48 weeks

"Many of my patients who were taking GLP-1 therapies were only tolerating 30 to 50% of their usual appetite, and they were struggling to get in enough protein

Orforglipron (Foundayo) New for 2026 The newest addition to the metabolic toolkit, this is a non-peptide oral medication recently approved by the FDA
