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The risks of hospitalization for heart failure (HR = 0.90, Fig

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Individual health history can make one option more appropriate, less appropriate, or unsuitable

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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs