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PMID: 35658024

10.7%) The SURMOUNT-4 trial had 783 obese adults without T2D take tirzepatide for 36 weeks (not blinded), working their way up to their maximum tolerated dose

References 1.World Health Organization

LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet alSemaglutide and cardiovascular outcomes in obesity without diabetes

At 24 weeks (the last point before people taking a placebo were eligible to switch to orforglipron), people taking a placebo had roughly gained 20 pounds back on average, no matter which drug they were taking originally

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