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therefore, additional studies are required to explore how changes in exposure influence their effectiveness.166 Moreover, this implies that tirzepatide more strongly affects the absorption of oral contraceptives and that this increased impact may be driven by rapid dose escalation.161 Unlike other pharmacodynamic effects, such as lowering blood glucose or reducing appetite, the delay in gastric emptying shows tachyphylaxis, with the effect gradually decreasing over time.169 Therefore, the investigators have suggested switching to a non-oral contraceptive option or adding a barrier method of contraception for 4 weeks after tirzepatide administration is initiated or if the dose is substantially increased.50,51 DDIs with Narrow Therapeutic Index Drugs Other clinical studies on DDIs have investigated the delayed gastric emptying effect of GLP-1 RA on the pharmacokinetics of drugs with narrow therapeutic index (Table 5)

Regular follow-up appointments every 4 to 8 weeks during the first 6 months help catch these adjustments early

At the population level, around 75% of users see symptoms fully resolve within 4 weeks as the body adapts

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