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5.4 Comparison with other anti-obesity medications The latest generation of GLP-1 receptor agonists signifies a substantial therapeutic improvement compared to earlier alternatives

Anyone comparing semaglutide versus tirzepatide should note that these lipid improvements are consistently observed across tirzepatide trials at a magnitude that clinical practice cannot ignore

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Additional factors such as increased release of adiponectin from adipose tissue, amelioration of insulin resistance in liver and peripheral tissues, and improved circulatory lipid profile all contribute to the reduced risk of ASCVD (267)