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At week 16, adjusted mean reduction in HbA1c from baseline was significantly greater with DAPA + SITA + MET ER ( 1.73% [ 19.0 mmol/mol]) compared to SITA + MET SR ( 1.28% [ 14.1 mmol/mol]

Because Glp1r mRNA is also expressed in the human OB 53 , it is intriguing to explore in future studies whether intranasal administration of GLP-1 agonists 54 could potentially exert their effects by acting in the OB (a site of persistent sensitivity to GLP-1 in obesity according to our data)

Finally, you must meet the above criteria for BMI

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[DOI] [PubMed] [Google Scholar] 41.Nicolau J., Nadal A., Sanchis P., Pujol A., Nadal C., Masmiquel L