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The first insertion is anterior, located where a vertical line drawn from the oral commissure intersects the inferior border of the mandible, corresponding anatomically to the insertion of the Depressor Labii Inferioris (DLI) muscle

This puts the peak nausea window during sleep

If the gastric emptying time shortens to just a few minutes as the anastomosis enlarges with time, chyme may dump into the small bowel

Treatment begins with a low dose that is gradually increased over several weeks to minimise gastrointestinal side effects and allow the body to adjust to the medication

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Stimulants have multifactorial physiologic impacts, due both to pharmacologic properties (adrenergic stimulation and vasoconstriction) and direct toxic effects