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DiMarchi had just left the company and become a professor of chemistry at Indiana University, and also wanted to develop obesity treatments that combine multiple drug targets

This slowed motility, combined with reduced food intake and often lower fiber and fluid consumption, creates the conditions for constipation

Poor food choices in this context do not just stall progress they actively undermine the metabolic outcomes you are trying to achieve

Many patients require ongoing treatment at maintenance doses to sustain results, making this a long-term therapeutic approach rather than a temporary intervention

However, in addition to their hypoglycemic effect, DPP-4i have also shown potent activities in the cardiovascular system, particularly in the regulation of blood pressure (BP)

That duration matters