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[15] In August 2024, the SURMOUNT-1 three-year study (176-week treatment period) found that tirzepatide reduced the risk of developing type 2 diabetes by 94% in adults with pre-diabetes and obesity or overweight

Consequently, these novel antidiabetic medications have been proven to be safe, and efficacious in multiorgan metabolic benefits

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PLoS One 6:e27081 Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-B activation by tumour necrosis factor requires the Akt serinethreonine kinase

There have been reports of gallbladder disease, including cholelithiasis and cholecystitis, possibly related to rapid weight loss

95% CI, 1.06-1.14), nausea and vomiting (HR = 1.3