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Muscle also drives your resting metabolic rate , lose a meaningful amount of it and you burn fewer calories at rest, which is part of why weight regain after stopping can be so stubborn

Reported incidences included nausea (5.922.2%), diarrhea (8.825.3%), vomiting (2.99.1%), and constipation (8.816.2%), with discontinuation rates reaching 19% in high-dose monthly regimens (816 mg) [62,63,64]

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Retatrutide Phase 2 data showed insulin resistance reductions of over 50% from baseline at higher doses, with fasting insulin levels dropping by up to 71%

Note to editors: A high-resolution version of the chart, additional data, and interviews with Noom research and clinical leaders are available on request