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The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

Roth JD, Hughes H, Kendall E, Baron AD, Anderson CM

Some patients benefit from staying at lower maintenance doses, while others advance toward higher ranges for maximum appetite suppression

Phase 2 weight loss (48 weeks): 8.7% at 2 mg maintenance 4 mg Weeks 58 First dose where therapeutic effects become clinically meaningful

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Enterolglucagon: A Specific Effect on Gastric Glands Isolated From the Rat Fundus