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Together, this multifactorial dilemma stipulates the necessity for the field to investigate novel pharmaceuticals and to extend the therapeutic utility of well-researched drugs already used in clinical practice

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J Clin Endocrinol Metab (2002) 87:2404.10.1210/jcem.87.1.8129 27 Perez-TilveDGonzalez-MatiasLAlvarez-CrespoMLeirasRTovarSDieguezCet alExendin-4 potently decreases ghrelin levels in fasting rats

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But translating preclinical findings into established human therapeutic strategies requires a level of evidence that does not yet exist for the most novel aspects of this work

The effects of LY2189265, a long-acting glucagon-like peptide-1 analogue, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: the EGO study
