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Image Credit: VectorMine / Shutterstock In a recent study published in the journal Frontiers in Pharmacology , researchers examined the potential role of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) in treating substance use disorders (SUDs)

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They can reduce levels of inflammatory biomarkers, such as C-reactive protein and inflammatory cytokines (eg, tumor necrosis factor-alpha and interleukin-6).100,101 This positively impacts various pathophysiological conditions, including type 2 diabetes, obesity, and non-alcoholic fatty liver disease.100102 In addition, inflammatory cytokines are reportedly involved in CYP gene expression, with the reduced cytokine levels-mediated by GLP-1 RA administration may alter CYP gene expression, potentially leading to changes in the pharmacokinetics of co-administered drugs (Figure 3).213 Finally, cardiovascular outcome trials have demonstrated that GLP-1 RAs offer beneficial effects on kidney function in type 2 diabetes and decrease the risk of major adverse kidney events in patients with type 2 diabetes and acute kidney disease.99,214 These renoprotective effects are expected to be driven by both direct and indirect mechanisms including reducing albuminuria, reducing inflammation, natriuresis and diuresis induction, and antioxidative effects.215 Moreover, GLP-1 RA treatment reportedly increased renal plasma flow and GFR in rats, leading to natriuresis and diuresis.216 It is known that changes in GFR can affect the elimination of many drugs including narrow therapeutic index drugs (aminoglycosides, lithium, digoxin), diuretics, and nonsteroidal anti-inflammatory drugs.217221 Therefore, pharmacokinetic changes in drugs mediated by increased GFR and renal plasma flow following GLP-1 RA administration may occur, and the impact of its mechanism of action need to be investigated in the future

Listening to Your Body GLP-1 medications significantly reduce appetite

Diabetes Obes Metab 2009

Implications for Long-Term Weight Management As such, they conclude: This evidence cautions against short-term use of weight management medications, emphasizes the need for further research into cost-effective strategies for long term weight control, and reinforces the importance of primary prevention. The study findings cast doubt on the notion that GLP-1 receptor agonists are a perfect cure for obesity, says a US researcher in a linked editorial