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Biological actions and therapeutic potential of the glucagon-like peptides

The difference between Exendin-4 and Exenatide lies primarily in the replacement of Ala with Valine (Val) at the 19th position and Asn with aspartic acid at the 28th position in Exendin-4

(Center) In macrophages, GLP-1 can significantly increase the expression of GLP-1 receptor through G protein-coupled receptor 119 (GPR119), enhance the activity of ABCA1, lead to the increase of apo AI, and thus promote intracellular cholesterol outflow

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

The overall rating for risk of bias obtained through the RoB2 tool was included as part of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach [11]

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