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Evaluated by fasting blood glucose, the network meta-analysis enrolled 47 randomised controlled trials with 17 163 subjects, confirming the placebo controlled effectiveness of all the 15 GLP-1RAs (fig 4, fig 5)

Nausea is most common when starting the medication or increasing the dose, but it typically improves as the body adjusts over time

Your team may advise a temporary pause based on current guidance

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No wonder payers are concerned about the short- and long-term costs

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations GLP-1RA, glucagon-like peptide-1 receptor agonists