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Charge: Many peptide molecules carry charges, increasing their interaction with the endothelial cells of the BBB, making it harder for them to cross

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After eating, the hormone is released in the gut

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These categories included genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication [2]