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Comparing Mechanisms of Action While both GLP-1 and GLP-3 influence metabolic function, their specific mechanisms show important differences: Insulin Secretion GLP-1 powerfully stimulates insulin secretion in a glucose-dependent manner, meaning it only enhances insulin release when blood glucose is elevated

While the research base for microdosing, specifically, is still developing, and lower-dose protocols are being explored, though clinical evidence for efficacy at sub-therapeutic doses remains limited

Peak is the compounded route, offering compounded semaglutide and tirzepatide from 503A pharmacies

The short circulating half-life ( t 1/2 ) of native GLP-1 (1 minute) makes it unfit as a therapeutic agent, and longer-acting GLP-1RAs with half-lives ranging from 2.5 hours to more than a week have been developed for the treatment of both type 2 diabetes and obesity (Table 1) (18)