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Just a few weeks after a Super Bowl commercial for a company that sells compounded GLP-1 anti-obesity medications ignited controversy, the Food and Drug Administration (FDA) has determined that the shortage of semaglutide (Ozempic, Wegovy and Rybelsus) is over

[DOI] [PMC free article] [PubMed] [Google Scholar] 441.Reiner T et al

2019;7:e000705

Preclinical studies suggest these drugs modulate reward pathways, reduce cravings, and influence stress responses

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Thus, target engagement studies can provide valuable information about the extent to which drugs are hitting their desired targets, and in the case of dual and triple agonists, the relative contributions of each component which can be used to better understand pharmacological effects