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A groundbreaking study published in Nature one of the worlds most prestigious scientific journals by Ohno T et al

The regain tends to be gradual at first, then accelerates as appetite signals return to pre-treatment patterns
(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy

Even more fascinating is the potential impact on our wider food culture, which is the angle we are exploring in this newsletter

Rapid or drastic weight loss can lead to something called hypothalamic amenorrhea 2

Retatrutide, tirzepatide, and semaglutide all activate the GLP-1 receptor, and combining them dramatically increases gastrointestinal side effects without proportional benefit
