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A groundbreaking study published in Nature one of the worlds most prestigious scientific journals by Ohno T et al

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The regain tends to be gradual at first, then accelerates as appetite signals return to pre-treatment patterns

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(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy

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Even more fascinating is the potential impact on our wider food culture, which is the angle we are exploring in this newsletter

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Rapid or drastic weight loss can lead to something called hypothalamic amenorrhea 2

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Retatrutide, tirzepatide, and semaglutide all activate the GLP-1 receptor, and combining them dramatically increases gastrointestinal side effects without proportional benefit

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