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This isn't necessarily clinical depression, though it can certainly feel similar

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[CrossRef] [PubMed] [Google Scholar] Neuroprotective effects of metformin through the modulation of neuroinflammation and oxidative stress

Cited 2024 Feb 4

However, one theory suggests that this is due to an increase in the expression of mammalian achaete-scute homolog 1 (Mash1), a protein crucial for neuronal development that is thought to encourage hippocampus regeneration
