losing too much weight on tirzepatide Do GLP-1 Drugs Cause Muscle Loss? What You Need to Know Unlocking Weight Loss with Tirzepatide
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The medication is initiated at a low dose and gradually increased specifically to minimise gastrointestinal side effects such as nausea, vomiting, diarrhoea, and decreased appetite

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Part of this was predictable

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After taking a break from dieting while travelling, they were surprised to find that they had maintained their weight, something that had never happened before