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Moreover, it is his or her task to define whether a patient needs to use a higher or lower dose of the medication based on his or her medical history

STEP (obesity, no diabetes required) The pivotal obesity trial, STEP-1 , was published as Wilding et al., NEJM 2021, PMID 33567185

In contrast, other medications, such as SGLT2 inhibitors and sulfonylureas, have different side effects, including risks of urinary tract infections and hypoglycemia, respectively

Ozempic is very commonly prescribed off-label for weight loss
They indicate the possible development of an abnormal connection between the colon and bladder, known as a colovesical fistula

Novo reported 23% vs 25.5% at 84 weeks , and that gap mattered because the studys primary goal was a non-inferiority claim
