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But people with obesity or metabolic syndrome dont

( Epub 20201007 )

Common side effects of both drugs include nausea, diarrhea, and constipation

According to Sinha et al., tirzepatide has better efficacy compared to many glucose-lowering medications such as dulaglutide, glargine, semaglutide, and insulin degludec and placebo drugs [14]

Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with type 2 diabetes mellitus and obesity: a randomized dose-ranging study

Most , but not all, of the drugs common side effects are gastrointestinal in nature and often improve over time as your body adjusts to the medication
