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Description
10% or more weight loss was achieved by 6.9% ( n = 2) in the placebo group, compared to 85.3% ( n = 29) in the semaglutide group

Tirzepatide did not impact metabolic adaptation during weight loss in people with obesity

Chronic low-grade inflammation accompanies obesity and contributes to cardiovascular disease, diabetes, and other conditions
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Another review comparing the two drugs shows 11% loss of body weight for tirzepatide and 7% with semaglutide over 36 weeks

Prediabetes (HbA 1c 3947 mmol/mol [5.76.4%] or FG 5.66.9 mmol/l) was associated with statistically significantly elevated long-term risks of any complication (HR 1.21 [95% CI 1.15, 1.27]) and the individual outcomes (HR ASCVD 1.38 [1.25, 1.52]
