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332,333,334 The NO produced by iNOS, as a free radical, can regulate intracellular signal transduction and modulate the inflammatory response

To harness these biological effects, scientists developed GLP-1 receptor agonists (GLP-1 RAs) drugs that imitate GLP-1 by activating the same receptors

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The pharmacokinetics of retatrutide are dose-proportional, with a half-life of approximately 6 days, making weekly dosing feasible [113]

This triple action is the main difference between retatrutide and many existing weight loss medicines

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