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This can lead to increased drug exposure and heightened risk of adverse effects, particularly with narrow therapeutic index drugs like dabigatran [141]

Fellow pharma powerhouse Roche has also jumped into the oral obesity arena with the $2.7 billion acquisition of Carmot Therapeutics in December 2023, giving it access to CT-388 and CT-868, both of which are dual agonists of the GLP-1 and GIP receptors with best-in-class potential for obesity, Roche said at the time

60 In a functional human beta-cell line, it demonstrated a dose-dependent increase in insulin secretion

Combined with a low-fat diet, 5-Amino-1MQ treatment rapidly normalized body weight and adiposity to levels matching age-matched lean animals, an outcome that diet alone could not achieve in the same timeframe

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These findings support the hypothesis that GLP-1 therapy, by reducing central adiposity, modulating sympathetic activation, and decreasing systemic inflammation, can ameliorate the underlying pathophysiology of OSA [2]