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Description
Accompanying TM1 movement to TM2, the extracellular tip of TM7 moves toward TM1 and the side-chain of K414 7.35b points to GLP-2 with formation of a salt bridge with Glu 9P
PMID: 39003287
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J Am Heart Assoc 2012
Receptor binding affinity (EC50, Human) = 5
Evidncias pr-clnicas e ensaios clnicos em modelos animais H mais de uma dcada, investigaes em roedores j apontavam para o potencial dos anlogos de GLP-1 em reverter ou prevenir os sinais de Alzheimer
