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Imaeda says
Cardiovascular Safety : The cardiovascular safety of tirzepatide has been evaluated and confirmed to date through a pre-specified meta-analysis of phase 2 and 3 randomized trials comparing tirzepatide with other placebo, insulin glargine, degludec, semaglutide, dulaglutide for a minimum of 26 weeks (including the GPGB, SURPASS 1,2,3,4,5, and J-mono studies) [67]
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Appetite, cravings, or weight are not changing much after a few months of using bupropion off-label for weight management
doi: 10.1002/dmrr.2924
