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Therefore, patients should expect to remain on oral semaglutide for the long term, potentially indefinitely, to support sustained weight management

[DOI] [PubMed] [Google Scholar] 75.Wang T, Masedunskas A, Willett WC, et al

Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol.78 The half-life of PEG-loxenatide is approximately 1 week.123 GLP-1RAs

Endogenous GLP-1 affects postprandial blood glucose by slowing gastric emptying and glucose absorption in healthy subjects (Schirra et al., 2006)

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