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This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%

In addition, the enteric nervous system (ENS), which is a recognized second brain that can regulate many GI functions independent of CNS action, can also act as an intermediate in relaying gut-derived information to the CNS 25

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Wegovy sales rose 18% year-over-year in Q3, down from 67% growth in Q2, while Ozempic slowed to 3% growth from 15% in the prior quarter